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Can an existing HIV medication slow the spread of COVID-19?

April 28, 2020: A team of scientists from St. Michael’s Hospital, Sinai Health and Sunnybrook Health Sciences Centre have launched a clinical trial to understand whether an existing drug used for HIV treatment and prevention may work to prevent COVID-19 infection.

The trial will examine whether post-exposure prophylaxis (PEP), which is a medication a person takes once they’ve been exposed to a virus to prevent infection, could halt or slow the spread of COVID-19 in groups of people who have been exposed to a confirmed case.

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The drug in question – Kaletra (lopinavir/ritonavir as PEP)- has long been used in this capacity to prevent HIV in those who have been exposed to the virus.

“Early studies of the use of this medication as post-exposure prophylaxis therapy in other coronaviruses such as SARS and MERS have been promising,” says Dr Darrell Tan, the study’s lead investigator who is also a scientist at the MAP Centre for Urban Health Solutions and an infectious disease physician at St. Michael’s.

“These are so-called ‘cousin’ viruses to COVID-19 and we want to understand whether lopinavir/ritonavir as PEP could impact its spread as well.”

Dr Tan, along with his co-leads Dr Allison McGeer, a senior clinician-scientist at the Lunenfeld-Tanenbaum Research Institute of Sinai Health, and Dr Adrienne Chan, a clinician-investigator at the Sunnybrook Research Institute, will collaborate with Toronto Public Health to identify confirmed cases of COVID-19.

They’ll then connect with those exposed to confirmed cases to enroll them in the study.

“A great many people from all across Toronto have worked together to get this study started,” says Dr McGeer. “We know we need to be finding solutions that contribute to stopping the spread of this disease as quickly as possible.”

The group of contacts of one patient with confirmed COVID-19 will be identified as a ‘cluster.’ Entire clusters will be randomized to receive either the medication or no intervention.

The team of researchers will then track whether or not participants develop COVID-19 by asking them to complete self-tests for the virus weekly. To limit contact, the research team will rely on courier and virtual or phone meetings with participants.

This type of study is called a ring trial design and was an effective method of using vaccines to eradicate smallpox and test treatments for Ebola.

“Kaletra is a drug that the HIV community has been using globally for two decades, and has also been commonly used at scale in low-resource settings.

This means it could be easily scaleable not just in Canada, but internationally if we are able to demonstrate its effectiveness in the prevention of COVID-19,” says Dr Chan, who is also an infectious disease physician at Sunnybrook Health Sciences Centre.

Participants randomized to receive the study drug will take it for 14 days, as this is the current estimated incubation period for COVID-19.

“If this strategy works, it could be a major turning point in our global effort to stop a virus where, as we have seen, the outcomes can be devastating,” says Dr Tan.

“We are hopeful that our work will bring us closer to understanding how to slow or contain the spread of COVID-19.”

https://eurekalert.org/pub_releases/2020-04/smh-cae042720.php

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