February 01 2021: “New data further examining Dupixent® (dupilumab) in diseases driven by type 2 inflammation including atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP) and eosinophilic esophagitis will be presented at the American Academy of Allergy, Asthma and Immunology (AAAAI) Virtual Annual Meeting, taking place from February 26 to March 1.
Abstracts have been published in an online supplement to The Journal of Allergy and Clinical Immunology (JACI), and include:
Atopic Dermatitis
New analyses evaluate the efficacy of Dupixent in children with severe atopic dermatitis with atopic comorbidities.
- Oral Abstract 461A (February 27, 5:10 pm – 6:25 pm ET): Dupilumab Improves Signs and Symptoms of Severe Atopic Dermatitis in Children Aged 6–11 Years with and without Comorbid Allergic Rhinitis, Lisa Beck
- Poster 99: Dupilumab Improves Signs and Symptoms of Severe Atopic Dermatitis in Children Aged 6–11 Years with and without Comorbid Asthma, Mark Boguniewicz
- Asthma
- New analyses evaluate the efficacy of Dupixent in moderate-to-severe asthma patients with an allergic phenotype over the long-term, as well as difficult-to-treat patients.
- Analyses also explore the potential of clinical remission in patients with moderate-to-severe disease with type 2 inflammation.
- Featured Poster 010 (February 26, 4:35 pm – 5:50 pm ET): Dupilumab Treatment Leads to Clinical Asthma Remission in Patients With Uncontrolled Moderate-to-Severe Asthma With Type 2 Inflammation, Ian Pavord
- Poster 183: Dupilumab Efficacy in GINA-Defined Difficult-to-Treat Type 2 Asthma Patients in the LIBERTY ASTHMA QUEST Study, Klaus Rabe
- Poster 184: Long-Term Efficacy of Dupilumab in Patients With Asthma With an Allergic Phenotype Rolled Over From LIBERTY ASTHMA QUEST: LIBERTY ASTHMA TRAVERSE Study, Lawrence Sher
Eosinophilic Esophagitis
New analysis further explores the impact of Dupixent on health-related quality of life (HRQoL) in patients with eosinophilic esophagitis.
The use of Dupixent in eosinophilic esophagitis is currently under clinical investigation and its safety and efficacy have not been fully evaluated by any regulatory authority.
·Poster 290: Dupilumab Improves Health-Related Quality of Life (HRQoL) and Reduces Symptom Burden in Patients with Eosinophilic Esophagitis (EoE): Results From Part A of a Randomized, Placebo-Controlled Three-Part Phase 3 Study, Evan Dellon
Chronic Rhinosinusitis with Nasal Polyposis
New analyses examine the burden on HRQoL in patients with severe CRSwNP, and the impact on objective and subjective disease measures with Dupixent treatment.
- Poster 423: A Responder Analysis to Demonstrate Dupilumab Treatment Effect Across Objective and Patient-Reported Subjective Endpoints For Patients With Severe Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Claus Bachert
- Poster 425: Health-Related Quality of Life Impairment Among Patients With Severe Chronic Rhinosinusitis With Nasal Polyps in the SINUS-24 Trial, Jorge Maspero
Cross-Indication Blood Eosinophils
New analysis assesses the effect of Dupixent on blood eosinophils over time across approved and investigational indications.
·Poster 447: Effect of Dupilumab Treatment on Blood Eosinophil Levels in Patients With Asthma, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP), Eosinophilic Esophagitis (EoE), or Atopic Dermatitis (AD), Michael Wechsler
Dupixent is a fully-human monoclonal antibody that inhibits the signaling of the interleukin-4 (IL-4) and interleukin-13 (IL-13) proteins.
Data from Dupixent clinical trials have shown that IL-4 and IL-13 are key drivers of the type 2 inflammation that plays a major role in atopic dermatitis, asthma, CRSwNP, and eosinophilic esophagitis.
About Dupixent
In the United States and Europe, Dupixent is approved for patients 6 years and older with moderate-to-severe atopic dermatitis, patients 12 years and older with moderate-to-severe asthma, and in adults with uncontrolled CRSwNP.
Dupixent is also approved in one or more of these indications in more than 60 countries around the world and more than 200,000 patients have been treated globally.
Dupixent is intended for use under the guidance of a healthcare professional and can be given in a clinic or at home by self-administration after training by a healthcare professional.
In children younger than 12 years of age, Dupixent should be administered by a caregiver.
Dupilumab Development Program
To date, dupilumab has been studied in more than 10,000 patients across 50 clinical trials in various chronic diseases driven by type 2 inflammation.
In addition to the currently approved indications, Sanofi and Regeneron are studying dupilumab in a broad range of diseases driven by type 2 inflammation or other allergic processes, including pediatric asthma (6 to 11 years of age, Phase 3), chronic obstructive pulmonary disease with evidence of type 2 inflammation (Phase 3), pediatric atopic dermatitis (6 months to 5 years of age, Phase 3), eosinophilic esophagitis (Phase 3), bullous pemphigoid (Phase 3), prurigo nodularis (Phase 3), chronic spontaneous urticaria (Phase 3), and food and environmental allergies (Phase 2).
These potential uses are investigational, and the safety and efficacy of dupilumab in these conditions have not been fully evaluated by any regulatory authority.
Dupilumab is being jointly developed by Sanofi and Regeneron under a global collaboration agreement.
About Regeneron
Regeneron (NASDAQ: REGN) is a leading biotechnology company that invents life-transforming medicines for people with serious diseases.
Founded and led for over 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to eight FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories.
Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, pain, infectious diseases and rare diseases.”
https://www.sanofi.com/en/media-room/press-releases/2021/2021-02-01-16-00-00
